How PRIALT May Work

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PRIALT may work
  • One of the ways a pain signal is transmitted from one nerve to another is through the N-type calcium channel4,9
  • Although the way PRIALT works in people is not known, animal studies suggest that PRIALT may work on pain transmission by binding to the N-type calcium channels in the spinal cord that send pain signals4,8
  • PRIALT is not an opioid (narcotic) and works differently on pain signals8,9

Safety Information

  • You should not be given PRIALT if you:
    • are allergic to PRIALT or any of its ingredients
    • have a condition or are receiving a treatment that would cause an injection in your spinal fluid to be unsafe
    • have or had a mental illness called psychosis (a loss of contact with reality, usually including delusions (false beliefs about what is taking place or who one is) or hallucinations (seeing or hearing things that aren’t real))
  • PRIALT may cause or worsen depression, which increases the risk of suicide. People 65 years of age and older have a higher risk for confusion with PRIALT. Taking certain other medicines along with PRIALT may raise the risk of having problems with thinking or alertness. Tell your doctor about all the medicines you are taking.

Your doctor may stop your treatment with PRIALT, give you other medicines, or require you to be hospitalized if you experience any of these symptoms.
Click here for additional Important Safety Information, and please see full Prescribing Information, including BOXED Warning, and discuss with your doctor.

References: 4. McGivern JG. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007;3(1):69-85. 8. PRIALT [package insert]. Palo Alto, CA: Jazz Pharmaceuticals; February 2013. 9. Miljanich GP. Ziconotide: neuronal calcium channel blocker for treating severe chronic pain. Curr Medicinal Chem. 2004;11(23):3029-3040.